Lewis Tierney, the 18-year-old son of Jason Robinson, is set to make his home bow for Wigan Warriors in Friday's Super League match against Castleford Tigers.
Tierney made a tryscoring debut in the Warriors' 33-32 win at Widnes Vikings earlier this month when he deputised for England full-back Sam Tomkins.
Tomkins, who scored his 23rd try of the season in Monday's 22-12 defeat at Warrington Wolves to go top of the Super League try chart, will miss his fourth match of the season with a swollen knee.
The league leaders will also be without England prop Lee Mossop after he sustained a hip injury at the Halliwell Jones Stadium.
Wigan were without nine senior players against the Wolves and, although stand-off Blake Green, hooker Michael McIlorum and prop Gil Dudson are expected to return to face the Tigers, coach Shaun Wane says he will not be able to finalise his line-up until the day of the game.
"Warrington was quite a physical game and we have some knocks from it so it is a testing time for us," Wane said.
"We are struggling with injuries and will take another look on Thursday. We will probably only know our team for sure on game day.
"But we know from the Widnes game that Lewis Tierney can fit in and do a job at full-back and it's the same with our front rowers - James Greenwood can perhaps come in."
Greenwood made his Wigan debut in the Challenge Cup tie against Leigh in April but has yet to play in Super League.
The Warriors, whose lead over Huddersfield Giants has been cut to just three points after going down to their first defeat since March, will have little time to lick their wounds but Wane will not use the short turnaround as an excuse.
"It is a short turnaround but we were given that date and we'll have to deal with it," Wane said.
"It's like an Easter period and it will be a test of the staff and a test of the players.
"It's just preparation this week. We're not going to get much work on the field with them, especially with Monday night's game being so physical.
"We're massaging them and giving them everything they need to be nice and fresh.
"It's a game I'm genuinely looking forward to to see how we respond. It will tell us something about the mental toughness of our players. I still expect a good performance and I know we'll get one."
Former Wigan prop Ben Davies is denied the chance of a return to the DW Stadium after pulling a hamstring in Castleford's 30-28 win over Hull FC last Friday.
It was his first game for the Tigers since joining them on a permanent deal following his release by Widnes. His place is set to go to former Huddersfield and St Helens prop Keith Mason.