Back-row forward Connor Farrell is set to make his Super League debut alongside brother Liam when Wigan Warriors look to go top of the table for the first time since last July.
Warriors coach Shaun Wane has included 20-year-old Connor as well as the England international who plays in the same position in his 19-man squad for tomorrow night's rearranged match against Widnes Vikings at the DW Stadium.
Connor, who has been playing on a dual registration for Workington, is likely to start on the bench.
"I'm excited to see how he goes," Wane said. "I want to see them both on the pitch at the same time."
Wane has also drafted in young hooker Callum Wright, while Dan Sarginson is set for a second outing at full-back after Matty Bowen was ruled out with a leg strain and with understudy Ryan Hampshire sidelined with a dislocated shoulder.
England winger Josh Charnley will make his first appearance for two months in place of youngster Joe Burgess, who has been a revelation in his first full season and was given permission by Wane to join the England squad for their mid-season training camp in Loughborough this week.
Charnley has been sidelined with a knee injury suffered in the Challenge Cup win at Dewsbury in early April and had been set to make his return via Workington on Sunday after being called into the Warriors squad.
Widnes coach Denis Betts switches Jack Owens to full-back in the absence of Rhys Hanbury, with former Bradford Bulls winger Patrick Ah Van recalled for only his third appearance of an injury-hit season.
"I'm more than confident putting Jack Owens at full-back," Betts said. "I think he's had some fantastic games this year there and it gives Patty a chance to get back in the side as well.
"Patty has been training well for the last two or three weeks. He's fit but he's just not playing any matches so we have to give him some matches to get the best out of him over the next three months."
Former Wigan centre Cameron Phelps, who was due to return from injury for Sunday's home game against Leeds, has been fast-tracked into the side following the loss of both Chris Dean and Stefan Marsh, who sustained head injuries in the 56-6 defeat by Hull FC last Friday.
Many eyes will be on former Wigan stand-off Kevin Brown, who has produced some of the best rugby of his career with the Vikings this year.
The former Huddersfield Giants skipper did not make England's 34-strong training squad but coach Steve McNamara insists places are still up for grabs and he will be at the DW Stadium tomorrow to check out his form.
"I think there are lots of players in Super League who are still capable of making the squad," McNamara said.
"This squad traditionally has had players who have missed out on mid-season camps. Go right back to Jamie Jones-Buchanan for the first one, Garreth Carvell was another and Brett Ferres last season forced his way into the World Cup squad so the door is never closed."
Widnes will be aiming to bounce back from their nine-try hammering by Hull while Wigan have the chance to leapfrog Leeds Rhinos and St Helens into pole position after the top three clubs all suffered defeats at the weekend.
The match is a round-two fixture which was postponed in February because of the Warriors' involvement in the World Club Challenge in Sydney.