Huddersfield Giants are set to bring in a trio of teenagers for Friday's trip to Castleford Tigers after losing skipper Danny Brough, full-back Scott Grix and utility forward David Faiumu to injury.
Brough, the reigning First Utility Super League Man of Steel, is the only player to have started all 20 of the Giants' matches this year but is facing a spell on the sidelines after picking up head and ankle injuries in the 36-10 home defeat by Salford Red Devils last Saturday.
Scotland's World Cup captain left the field on the hour clutching his jaw after being the victim of a late and high tackle from Salford forward Lama Tasi.
"He has a sore jaw and fortunately there's no break but in that incident he did some damage to an ankle," Huddersfield coach Paul Anderson said.
"He's a small tear in his ligament and he was also concussed
"Broughy is tough and I've had to sit down and basically convince him he's not right to play because he's captain and he wants to lead the team. Hopefully it's not too long."
Anderson is set to switch Luke Robinson back into the halves alongside Kyle Wood and give a first appearance of the season to 18-year-old hooker Kruise Leeming in the continuing absence of first-choice number nine Shaun Lunt with a nagging calf strain.
Full-back Jake Connor, 19, should make his fourth senior appearance in place of Grix, who is facing a month on the sidelines with a groin problem, while scrum-half Jack Miller, also 19, will also be named in Anderson's 19-man squad.
With the experienced Faiumu also out with a shoulder injury, Anderson has little option but to turn to youth and is hoping to secure similar results to the ones enjoyed by Wigan Warriors boss Shaun Wane and St Helens coach Nathan Brown in similar circumstances this year.
"They're all brave and they've all had opportunities in the past," Anderson said. "You wouldn't want to play them all together but Waney and Browny have done it this year and they've done alright. They're here for a reason."
In the absence of Brough, second-row forward Brett Ferres will captain the team against his old club and his England team-mate Leroy Cudjoe will take on the goal-kicking duties.
Meanwhile, Huddersfield have signed England youth international Izaac Farrell on a two-year professional contract.
The 16-year-old half-back comes from the same junior club, Newsome Panthers, as Michael Lawrence and Cudjoe.
Huddersfield head of youth development Andy Kelly said: "I've enjoyed working with Izaac so far and in doing so you can see the potential in him to go further."